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Journal Articles:

Mathewson K.J., McGowan P.O., de Vega W.C., Van Lieshout R.J., Morrison K.M., Saigal S., and Schmidt L.A. (2020). DNA methylation profiles in adults born at extremely low birth weight. Development and Psychopathology.

Savoy C.D., Schmidt L.A., McGowan P.O., Saigal S., and Van Lieshout R.J. (2020). Extremely low birth weight influences the relationship between stress and telomere length in adulthood. Journal of Developmental Origins of Health and Disease. 

Lauby S.C. and McGowan P.O. (2020). Early life variations in temperature exposure affect the epigenetic regulation of the paraventricular nucleus in female rat pups. Proceedings. Biological Sciences.

Wijenayake S., Rahman M.F., Lum C.M.W., de Vega W.C., Sasaki A., and McGowan P.O. (2020). Maternal high-fat diet induces sex-specific changes to glucocorticoid and inflammatory signaling in response to corticosterone and lipopolysaccharide challenge in adult rat offspring. Journal of Neuroinflammation.

Abuaish S., Tse E.K. and McGowan P.O. (2020). Perinatal high-fat diet impairs pup retrieval and induces sex-specific changes in ultrasonic vocalization characteristics of rat pups. Developmental Psychobiology.

Matthews S.G. and McGowan P.O. (2019). Developmental programming of the HPA axis and related behaviours: epigenetic mechanisms. The Journal of Endocrinology.

Lauby S.C., Chatterjee D., Pan P., McGowan P.O. and Fleming A.S. (2019). Inter-individual maternal care received and genotype interactions affect dopaminergic phenotypes in female rat offspring. Journal of Neuroendocrinology.

McGowan P.O. and Matthews S.G. (2018). Prenatal Stress, Glucocorticoids, and Developmental Programming of the Stress Response. Endocrinology.

Herrera S., de Vega W.C., Ashbrook D., Vernon S.D., and McGowan P.O. (2018). Genome-epigenome interactions associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Epigenetics.

Abuaish S., Spinieli R.L., and McGowan P.O. (2018). Perinatal high fat diet induces early activation of endocrine stress responsivity and anxiety-like behavior in neonates. Psychoneuroendocrinology.

Pan P., Lawson D.O., Dudin A., Vasquez O.E., Sokolowski M.B., Fleming A.S. and McGowan P.O. (2018). Both maternal care received and genotype influence stress-related phenotype in female rats. Developmental Psychobiology.

St-Cyr S., Abuaish S., Welch K.C.Jr., and McGowan P.O. (2018). Maternal predator odour exposure programs metabolic responses in adult offspring. Scientific Reports.

de Vega W.C., Erdman L., Vernon S.D., Goldenberg A., and McGowan P.O. (2018). Integration of DNA methylation & health scores identifies subtypes in myalgic encephalomyelitis/chronic fatigue syndrome. Epigenomics.

St-Cyr S. and McGowan P.O. (2018). Adaptation or pathology? The role of prenatal stressor type and intensity in the developmental programing of adult phenotype. Neurotoxicology and Teratology.

Sasaki A., McGowan P.O. and Erb S. (2018). A study of the effects of maternal high fat diet on behavioural responses to acute and repeated administrations of cocaine in rat offspring. Neuroscience Letters.

St-Cyr S., Abuaish S., Spinieli R.L., and McGowan P.O. (2018). Maternal predator odor exposure in mice programs adult offspring social behavior and increases stress-induced behaviors in semi-naturalistic and commonly-used laboratory tasks. Frontiers in Behavioral Neuroscience.

Ashbrook D.G., Hing B., Michalovicz L.T., Kelly K.A., Miller J.V., de Vega W.C., Miller D.B., Broderick G., O'Callaghan J.P. and McGowan P.O. (2018). Epigenetic impacts of stress priming of the neuroinflammatory reponse to sarin surrogate in mice: a model of Gulf War illness. Journal of Neuroinflammation.

de Vega W.C. and McGowan P.O. (2017). The epigenetic landscape of myalgic encephalomyelitis/chronic fatigue syndrome: deciphering complex phenotypes. Epigenomics.

St-Cyr S., Abuaish S., Sivanathan S., and McGowan P.O. (2017). Maternal programming of sex-specific responses to predator odor stress in adult rats. Hormones and Behavior.

de Vega W.C., Herrera S. Vernon S.D., and McGowan P.O. (2017). Epigenetic modifications and glucocorticoid sensitivity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). BMC Medical Genomics.

Jenkins J.*, McGowan P.O.* and Knafo A.* (2015). Parent-offspring transaction: mechanisms and the value of within family deisgns. Hormones and Behavior.

St-Cyr, S. and McGowan P.O. (2015). Programming of stress-related behavior and epigenetic neural gene regulation in mice offspring through maternal exposure to predator odor. Frontiers in Behavioral Neuroscience.

Sivanathan S., Thavartnam K., Arif S., Elegino T., McGowan P.O. (2015).Chronic high fat feeding increases anxiety-like behaviour and reduces transcript abundance of glucocorticoid signaling genes in the hippocampus of female rats. Behavioural Brain Research.

McGowan P.O. and Roth T.L. (2015).Epigenetic pathways through which experiences become linked with biology. Development and Psychopathology.

de Vega W.C., Vernon S.D., McGowan P.O. (2014). DNA methylation modifications associated with Chronic Fatigue Syndrome. PLoS ONE. Aug 11;9(8):e104757.

Pan P., Fleming A.S., Lawson D., Jenkins J.M., McGowan P.O. (2014). Within- and between-litter maternal care alter behavior and gene regulation in female offspring. Behavioral Neuroscience. Dec; 128(6):736-48.

Lavergne S.G., McGowan P.O., Krebs C.J., Boonstra R. (2014). Impact of high predation risk on genome-wide hippocampal gene expression in snowshoe hares. Oecologia. Nov;176(3):613-24.

Sasaki A., de Vega W., Sivanathan S., St-Cyr S., McGowan P.O.(2014). Maternal high fat diet alters anxiety behavior and glucocorticoid signaling in adolescent offspring. Neuroscience. July 11; 272: 92-101.

Sasaki A., Constantinof A., Pan P., Kupferschmidt D.A.,McGowan P.O., Erb, S. (2014). Cocaine exposure prior to pregnancy alters the psychomotor response to cocaine and transcriptional regulation of the dopamine D1 receptor in adult male offspring. Behavioural Brain Research. Feb 25. pii: S0166-4328(14)00092-8. doi: 10.1016/j.bbr.2014.02.017.

McGowan, P.O. (2013) Epigenomic mechanisms of early adversity and HPA dysfunction: Considerations for PTSD research. Frontiers in Molecular Psychiatry. Sep 26;4:110.

Sasaki A., de Vega W.C., St-Cyr S., Pan P., McGowan P.O. (2013) Perinatal high fat diet alters glucocorticoid signaling and anxiety behavior in adulthood. Neuroscience. June 14;240:1-12.

Sasaki A., de Vega W.C., McGowan P.O. (2013) Biological embedding in mental health: An epigenomic perspective. Biochemistry and Cell Biology. Feb 91(1):14-21.

Suderman M.*, McGowan P.O.*, Sasaki A.*, Huang T.C.T., Hallett M., Meaney M.J., Turecki G., Szyf M. (2012) Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus. Proceedings of the National Academy of Sciences. Oct 16;109 Suppl 2:17266-72.*equal contribution.

McGowan P.O. (2012) Epigenetic clues to the biological embedding of early life adversity. Biological Psychiatry. Jul 1;72(1):4-5.

Love O.*, McGowan P.O.*, Sheriff M.J.* (2012) Maternal adversity and ecological stressors in natural populations: the role of stress axis programming in individuals, w ith implications for populations and communities. Functional Ecology.  *equal contribution.

McGowan P.O.*, Suderman M.*, Sasaki A.*, Huang T.C., Hallett M., Meaney M.J., Szyf M. (2011) Broad epigenetic signature of maternal care in the brain of adult rats. PLoS One. Feb 28;6(2):e14739.  *equal contribution.   

McGowan P.O., Hope T.A., Meck W.H., Kelsoe G., Williams C.L. (2011) Impaired social recognition memory in recombination activating gene 1-deficient mice. Brain Research  Apr 6;1383:187-95. 

Clinchy, M., Schulkin, J., Zanette, L.Y., Sheriff, M.J., McGowan, P.O., Boonstra, R. (2010) The neurological ecology of fear: insights neuroscientists and ecologists have to offer one another. Frontiers in Behavioral Neuroscience. 4;21: Epub 2011 Apr 25.

McGowan P.O. and Szyf, M. (2010). Environmental epigenomics: Understanding the effects of parental care on the epigenome. Essays in Biochemistry.. Sep 20; 48(1):275-87.

McGowan, P.O. and Szyf, M. (2010) The epigenetics of social adversity in early life: Implications for mental health outcomes. Neurobiology of Disease. Jul; 39(1):66-72.

McGowan, P.O., Sasaki A., D’Alessio A.C., Dymov S., Labonte, B., Szyf M., Turecki G., Meaney M.J. (2009) Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nature Neuroscience. Mar 12(3): 342-8 (full article) *Faculty of 1000 Biology: Factor 9.0 ‘Exceptional’.

Ernst C., McGowan P.O., Deleva V., Meaney M.J., Szyf M., Turecki G. (2008) The effects of pH on DNA methylation state: in-vitro and post- mortem brain studies. Journal of Neuroscience Methods. Sep 15; 174(1): 123-5.

McGowan, P.O., Meaney, M.J., Szyf, M. (2008) Diet and the epigenetic (re)programming of phenotypic differences in behavior. Brain Research. Oct 27; 1237: 12-24. *Faculty of 1000 Medicine: Factor 6.0 'Must read'.

McGowan, P.O., Sasaki, A., Huang, T.C.T., Unterberger, A., Suderman, M., Ernst, C., Meaney, M.J., Turecki, G., Szyf, M. (2008) Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain. PLoS ONE 3(5):e2085.

Szyf M., McGowan P., Meaney M.J. (2008) The social environment and the epigenome. Environmental and Molecular Mutagenesis. 49: 46-60.

McGowan P.O., Kato T. (2008) Epigenetics in mood disorders. Environmental Health and Preventive Medicine. 13: 16-24.

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Book Chapters:

de Vega W.C., Hussain A., McGowan P.O. (accepted). Reduced Representation Bisulfite Sequencing (RRBS) and cell sorting prior to DNA methylation analysis in Psychiatric Disorders. In: Stefanska B. and MacEwan D.J., (eds.). Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases. Springer Press.

McGowan P.O. (2015) Epigenetic mechanisms of perinatal programming: Translational approaches from rodent to human and back. In: Antonelli, M. editor. Perinatal programming of neurodevelopment. Springer Press.

McGowan P.O., Sasaki A., Roth T.L. (2014). The social environment and epigenetics in psychiatry. In: Peedicayil J, Grayson D. and Avramopoulos D. (eds.). Epigenetics in psychiatry. Elsevier.

McGowan, P.O., Meaney M.J., Szyf, M. (2011). Epigenetics, phenotype, diet and behavior. In: Preedy, V. R., Martin, C., and Watson, R. R., editors. Handbook of Behavior, Diet and Nutrition. Springer Press.

Szyf, M. McGowan, P.O., Turecki, G., Meaney M.J. (2010). The social environment and the epigenome. In: Worthman, C., Plotsky, P., Schechter, D., and Cummings, C. editors. Formative Experiences: The Interaction of Caregiving, Culture, and Developmental Psychobiology. Cambridge University Press.

McGowan, P.O., Meaney M.J., Szyf, M. (2009) The epigenetic reprogramming of phenotypic differences in behavior. In: Pintér, B. and Mészáros, Z., editors. Epigenetics: Mechanisms, Functions and Human Effects. Nova Science, Inc.

Szyf, M., Weaver, I., Provencal, N., McGowan, P.O., Tremblay, R.E., Meaney, M.J. (2009) Epigenetics and Behaviour. In: Tremblay, R.E., van Aken, M.A.G., and Koops, W., editors. Development and Prevention of Behaviour Problems: From Genes to Social Policy. Psychology Press.

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Recent Conference Abstracts:

St-Cyr S., Abuaish S., Welch K.C., and McGowan P.O. (2015). Maternal programming of adult behavior and metabolism by prenatal predator odor exposure. Society for Neuroscience, Oct 2015, Chicago, Il, USA.

Abuaish S., Lum C.M.W., and McGowan P.O. (2015). Impacts of maternal stress and high fat diet on HPA axis programming in offspring. Society for Neuroscience, Oct 2015, Chicago, Il, USA.

de Vega W.C., Herrera S., Vernon S.D., and McGowan P.O. (2015). The DNA Methylome and the HPA Axis Response in Chronic Fatigue Syndrome. World Congress in Psychiatric Genetics. Oct 2015, Toronto, ON, Canada.

Lum C.M.W., de Vega W.C., Abuaish S., Sasaki, S., and McGowan, P.O. (2015). Maternal high-fat diet exposure alters the transcriptional response to corticosterone and lipopolysaccharide in the amygdala and hippocampus of rats during adulthood. Southern Ontario Neuroscience association 2015 annual meeting. McMaster University, May 1, 2015, Hamilton, Ontario, Canada

Lavergne SG, McGowan PO, Krebs CK, Boonstra R (2014) The impact of predation risk on gene expression in the brains of snowshoe hares during the peak and decline phases of the 10-year cycle. Gordon Research Conference: Predator-Prey Interactions, January 2014, Ventura, CA, USA.

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